STATE OF THE ART AND INTEGRATED PROCESS DESIGN FOR MICROBIOREACTOR SYSTEMS- A REVIEW

  Sirajo Lawal,  Ali Abubakar Mohammed,  Musa Lawal

Over the years, microbioreactors have been equipped with a variety of tools for online monitoring and measuring of environmental conditions and assessing the physiological state of microorganisms. Microorganisms have played an essential role in producing everyday commodities, such as alcohol, beverages, enzymes. Micro scale system such as microbioreactor offers the potential to develop disposable and miniaturized version of conventional bioreactor. Microbioreactors systems combine the ease of handling of shake flask operations while preserving the online sensing and control capabilities of stirred tank bench-scale bioreactors. It offers academia and the industry the capacity to acquire real-time experimental data through cheap and high-throughput experimentation under well-controlled conditions. However, in spite of development of microbioreactor technology, new challenges still exist. One obvious challenge is the need for efficient strategies for determining the optimal operating condition where both the design and control objectives of obtaining optimal throughput screening in a microbioreactor can be best achieved. Such strategy will increase the efficiency of the reactor and reduce its working hours drastically in addition to other advantages of performing experiments in a microbioreactor system. Current microbioreactor process design and control is analyzed in this review paper, focusing on state-of-the-art and proposing a new strategy for determining the optimal operating conditions where both the design and control objectives of obtaining optimal throughput screening with a microbioreactor can be achieved.

Keywords- microbioreactors, attainable region, Oxygen demand, Dissolved oxygen

Unique Identification Number - IJEDR1401215
Page Number(s) - 1205-1210
Pubished in - Volume 2 | Issue 1 | March 2014
DOI (Digital Object Identifier) -   
Publisher - IJEDR (ISSN - 2321-9939)

  Sirajo Lawal,  Ali Abubakar Mohammed,  Musa Lawal,   "STATE OF THE ART AND INTEGRATED PROCESS DESIGN FOR MICROBIOREACTOR SYSTEMS- A REVIEW", International Journal of Engineering Development and Research (IJEDR), ISSN:2321-9939, Volume.2, Issue 1, pp.1205-1210, March 2014, Available at :http://www.ijedr.org/papers/IJEDR1401215.pdf